Diarrhea is still the most common disease of persons visiting developing countries doxycycline hyclate 100. Of the 16 million people in the industrialized countries, annually visiting developing countries, approximately 1/3 of the ill diarrhea. Incidence travelers' diarrhea significantly vary in different countries.

Virtually all cases are caused by ingested microorganisms in the use of food or water contaminated with fecal matter. Especially high risk are raw vegetables, meat and seafood. Common cause of intestinal infections is enterotoxigenic Escherichia coli, responsible for 50-75% of cases of diarrhea. In its various strains m.ira different regions can produce both heat-labile and heat-stable toxin or simultaneously both. In most other cases can be distinguished, and other activators of intestinal infections, but the apparent large regional differences in terms of their prevalence. For example, in Mexico, Shigella cause up to 10% of cases of travelers' diarrhea, but in North Africa, they are rarely the cause of the disease. Vibrio parahemolyticus relatively common cause of travelers diarrhea among Japanese tourists visiting Asia, but not South America. In general, viruses (rotaviruses, Norfolkpodobnye viruses) and protozoa (amoeba, giardia) is less than 10% of cases cause disease.

The development of diarrhea associated with the views of the pathogen, and in most cases even caused by Shigella are usually docked on their own and are not accompanied by serious consequences in previously healthy individuals.

Travelers' diarrhea usually begin abruptly with severe intestinal problems, cramping abdominal pain, nausea and often a slight increase in body temperature. In most cases, fluid losses do not reach a large extent, and diarrhea symptoms gradually disappear within 3-5 days.

The only reliable method of preventing diarrhea is the rejection of the use of contaminated water and food, which is practically very difficult to carry out, in most cases when traveling to developing countries. In different countries, according to well-controlled studies, a significant preventive effect was observed after administration of two antibacterial drugs: doxycycline and trimethoprim - sulfamethoxazole (Bactrim). In this case, the incidence could reduce 50-86%. However, given the potential risk of prophylactic administration of these drugs and generally self-limited during diarrhea, it is not recommended to appoint them widely. However, it is desirable to tourists in advance acquired therapeutic doses of effective antimicrobial drugs before traveling to areas with high risk of disease and taking them immediately with the development of diarrhea, without using potentially dangerous accidentally bought "drugs from the stomach."